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1

Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine

Geoghegan, Kieran F., Stroh, Justin G.

Journal:

Bioconjugate Chemistry

Year:

1992

Language:

english

File:

PDF, 1.40 MB

english, 1992

2

Risk factors associated with increased mortality of farmed Pacific oysters in Ireland during 2011

Clegg, Tracy A., Morrissey, Teresa, Geoghegan, Fiona, Martin, S. Wayne, Lyons, Kieran, Ashe, Seán, More, Simon J.

Journal:

Preventive Veterinary Medicine

Year:

2014

Language:

english

File:

PDF, 1.82 MB

english, 2014

3

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Wu, Jiang, Shin, Julia, Williams, Cara M. M., Geoghegan, Kieran F., Wright, Stephen W., Limburg, David C., Sahasrabudhe, Parag, Bonin, Paul D., Lefker, Bruce A., Ramsey, Simeon J.

Journal:

Year:

2014

Language:

english

File:

PDF, 499 KB

english, 2014

4

Correction: Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

Wu, Jiang, Shin, Julia, Williams, Cara M. M., Geoghegan, Kieran F., Wright, Stephen W., Limburg, David C., Sahasrabudhe, Parag, Bonin, Paul D., Lefker, Bruce A., Ramsey, Simeon J.

Journal:

Year:

2015

Language:

english

File:

PDF, 146 KB

english, 2015

5

Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment

Schülke, Jan-Philip, McAllister, Laura A., Geoghegan, Kieran F., Parikh, Vinod, Chappie, Thomas A., Verhoest, Patrick R., Schmidt, Christopher J., Johnson, Douglas S., Brandon, Nicholas J.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 18.67 MB

english, 2014

6

Biochemical applications of mass spectrometry in pharmaceutical drug discovery

Kieran F. Geoghegan, Michele A. Kelly

Journal:

Mass Spectrometry Reviews

Year:

2005

Language:

english

File:

PDF, 583 KB

english, 2005

7

Spectral properties of cobalt carboxypeptidase A. Interaction of the metal atom with anions

Geoghegan, Kieran F., Holmquist, Barton, Spilburg, Curtis A., Vallee, Bert L.

Journal:

Year:

1983

Language:

english

File:

PDF, 745 KB

english, 1983

8

Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function

Ping Du, Pat Loulakis, Chun Luo, Anil Mistry, Samuel P. Simons, Peter K. LeMotte, Francis Rajamohan, Kristina Rafidi, Kevin G. Coleman, Kieran F. Geoghegan, Zhi Xie

Journal:

Protein Expression and Purification

Year:

2005

Language:

english

File:

PDF, 393 KB

english, 2005

9

ACUTE RENAL FAILURE IN OBSTETRICS

O'Driscoll, Kieran, Geoghegan, Francis

Journal:

Year:

1965

Language:

english

File:

PDF, 358 KB

english, 1965

10

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang

Journal:

Year:

2018

Language:

english

File:

PDF, 226 KB

english, 2018

11

The 2.0 Å crystal structure of the ERα ligand-binding domain complexed with lasofoxifene

Felix F. Vajdos, Lise R. Hoth, Kieran F. Geoghegan, Samuel P. Simons, Peter K. LeMotte, Dennis E. Danley, Mark J. Ammirati, Jayvardhan Pandit

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 627 KB

english, 2007

12

The discovery of four distinct glutamate dehydrogenase genes in a strain of Halobacterium salinarum

Lorna M. Ingoldsby, Kieran F. Geoghegan, Bronagh M. Hayden, Paul C. Engel

Journal:

Year:

2005

Language:

english

File:

PDF, 175 KB

english, 2005

13

Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes

Gertsik, Natalya, am Ende, Christopher W., Geoghegan, Kieran F., Nguyen, Chuong, Mukherjee, Paramita, Mente, Scot, Seneviratne, Uthpala, Johnson, Douglas S., Li, Yue-Ming

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.64 MB

english, 2017

14

Escherichia coli expression, purification and characterization of functional full-length recombinant α2β2γ3 heterotrimeric complex of human AMP-activated protein kinase

Francis Rajamohan, Melissa S. Harris, Richard K. Frisbie, Lise R. Hoth, Kieran F. Geoghegan, James J. Valentine, Allan R. Reyes, James A. Landro, Xiayang Qiu, Ravi G. Kurumbail

Journal:

Protein Expression and Purification

Year:

2010

Language:

english

File:

PDF, 911 KB

english, 2010

15

Comparison of the N-terminal sequence of NADH oxidase from Thermus aquaticus with those of other flavoenzymes

Toomey, David, Mayhew, Stephen G., Lanzetti, Anthony J., Geoghegan, Kieran F.

Journal:

Biochemical Society Transactions

Year:

1996

Language:

english

File:

PDF, 136 KB

english, 1996

16

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Qiu, Xiayang, Mistry, Anil, Ammirati, Mark J, Chrunyk, Boris A, Clark, Ronald W, Cong, Yang, Culp, Jeffrey S, Danley, Dennis E, Freeman, Thomas B, Geoghegan, Kieran F

Journal:

Nature Structural and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 832 KB

english, 2007

17

32 Probing the stability of the tertiary structure of glutamate dehydrogenase by limited proteolysis

AGHAJANIAN, SUREN, HOVSEPYAN, MANUSHAK, GEOGHEGAN, KIERAN F., CHRUNYK, BORIS A., ENGEL, PAUL C.

Journal:

Biochemical Society Transactions

Year:

1998

Language:

english

File:

PDF, 131 KB

english, 1998

18

[Part 1: Biological Sciences] || Cryospectrokinetic Characterization of Intermediates in Biochemical Reactions: Carboxypeptidase A

David S. Auld, Alphonse Galdes, Kieran F. Geoghegan, Barton Holmquist, Richard A. Martinelli and Bert L. Vallee

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 1.20 MB

english, 1984

19

Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor

Lise R. Hoth, Douglas H. Tan, Ing-Kae Wang, Paul A. Wengender, Michelle A. Thompson, Ajith V. Kamath, Kieran F. Geoghegan

Journal:

Protein Expression and Purification

Year:

2007

Language:

english

File:

PDF, 404 KB

english, 2007

20

A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS

Xu, Hua, Hett, Erik C., Gopalsamy, Ariamala, Parikh, Mihir D., Geoghegan, Kieran F., Kyne, Robert E., Menard, Carol A., Narayanan, Arjun, Robinson, Ralph P., Johnson, Douglas S., Tones, Michael A., Jo

Journal:

Molecular BioSystems

Year:

2015

Language:

english

File:

PDF, 2.84 MB

english, 2015

21

Site-directed double fluorescent tagging of human renin and collagenase (MMP-1) substrate peptides using the periodate oxidation of N-terminal serine. An apparently general strategy for provision of energy-transfer substrates for proteases

Geoghegan, Kieran F., Emery, Michael J., Martin, William H., McColl, Alexander S., Daumy, Gaston O.

Journal:

Bioconjugate Chemistry

Year:

1993

Language:

english

File:

PDF, 1.01 MB

english, 1993

22

Expression of human plasminogen activator inhibitor type-1 (PAI-1) in Escherichia coli as a soluble protein comprised of active and latent forms. Isolation and crystallization of latent PAI-1

Arthur E. Franke, Dennis E. Danley, Frank S. Kaczmarek, Steven J. Hawrylik, Robert D. Gerard, S.Edward Lee, Kieran F. Geoghegan

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1990

Language:

english

File:

PDF, 835 KB

english, 1990

23

Binding to the Low-Density Lipoprotein Receptor Accelerates Futile Catalytic Cycling in PCSK9 and Raises the Equilibrium Level of Intramolecular Acylenzyme

Geoghegan, Kieran F., Hoth, Lise R., Varghese, Alison H., Lin, Wen, Boyd, James G., Griffor, Matthew C.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.73 MB

english, 2009

24

Reduction of biological activity of murine recombinant interleukin-1β by selective deamidation at asparagine-149

Gaston O. Daumy, Cheryl L. Wilder, Joseph M. Merenda, Alexander S. McColl, Kieran F. Geoghegan, Ivan G. Otterness

Journal:

Year:

1991

Language:

english

File:

PDF, 1.21 MB

english, 1991

25

Dye-Pair Reporter Systems for Protein−Peptide Molecular Interactions

Geoghegan, Kieran F., Rosner, Philip J., Hoth, Lise R.

Journal:

Bioconjugate Chemistry

Year:

2000

Language:

english

File:

PDF, 355 KB

english, 2000

26

ALTERNATIVE REDUCING AGENTS FOR REDUCTIVE METHYLATION OF AMINO GROUPS IN PROTEINS

KIERAN F. GEOGHEGAN, JUDY C. CABACUNGAN, HENRY B.F. DIXON, ROBERT E. FEENEY

Journal:

Chemical Biology & Drug Design

Year:

1981

Language:

english

File:

PDF, 572 KB

english, 1981

27

Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene

Niamh Banville, Robert Geraghty, Edward Fox, Dermot T. Leahy, Andrew Green, Denise Keegan, Justin Geoghegan, Diarmuid O'Donoghue, John Hyland, Kieran Sheahan

Journal:

Human Pathology

Year:

2006

Language:

english

File:

PDF, 849 KB

english, 2006

28

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Hett, Erik C., Xu, Hua, Geoghegan, Kieran F., Gopalsamy, Ariamala, Kyne, Robert E., Menard, Carol A., Narayanan, Arjun, Parikh, Mihir D., Liu, Shenping, Roberts, Lee, Robinson, Ralph P., Tones, Michae

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

29

Modification of amyloid-β(1–40) by a protease inhibitor creates risk of error in mass spectrometric quantitation of amyloid-β(1–42)

James J. Conboy, Kathleen G. Wood, Mary E. Lame, Robert A. Durham, Kieran F. Geoghegan

Journal:

Analytical Biochemistry

Year:

2008

Language:

english

File:

PDF, 188 KB

english, 2008

30

Preliminary x-ray analysis of crystals of plasminogen activator inhibitor-1

Dr. Elizabeth J. Goldsmith, Chen Sheng-Cheng, Dennis E. Danley, Robert D. Gerard, Kieran F. Geoghegan, James Mottonen, Arne Strand

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 341 KB

english, 1991

31

Initiation of translation at an upstream non-AUG codon accounting for N-terminally extended minor forms of recombinant proteins expressed in insect cells

Kieran F. Geoghegan, Xidong Feng, Jeanne S. Chang, Kerry Kelleher, Paul W. Wu, Laura Lin, Francis Rajamohan

Journal:

Protein Expression and Purification

Year:

2011

Language:

english

File:

PDF, 840 KB

english, 2011

32

Protein Science

Review by: Kieran F. Geoghegan

Journal:

Year:

1980

Language:

english

File:

PDF, 116 KB

english, 1980

33

Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS 4 )

Geoghegan, Kieran F., Varghese, Alison H., Feng, Xidong, Bessire, Andrew J., Conboy, James J., Ruggeri, Roger B., Ahn, Kay, Spath, Samantha N., Filippov, Sergey V., Conrad, Steven J., Carpino, Philip

Journal:

Year:

2012

Language:

english

File:

PDF, 4.86 MB

english, 2012

34

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry

Ballard, T. Eric, Dahal, Upendra P., Bessire, Andrew J., Schneider, Richard P., Geoghegan, Kieran F., Vaz, Alfin D. N.

Journal:

Rapid Communications in Mass Spectrometry

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

35

Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

Michael A. Letavic, Matt Z. Axt, John T. Barberia, Thomas J. Carty, Dennis E. Danley, Kieran F. Geoghegan, Nadia S. Halim, Lise R. Hoth, Ajith V. Kamath, Ellen R. Laird, Lori L. Lopresti-Morrow, Kim F

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

36

Fluorescence-based continuous assay for the aspartyl protease of human immunodeficiency virus-1

Kieran F. Geoghegan, Robin W. Spencer, Dennis E. Danley, Leonard G. Contillo Jr., Glenn C. Andrews

Journal:

Year:

1990

Language:

english

File:

PDF, 418 KB

english, 1990

37

Characterization of a novel 14 kDa bile acid-binding protein from rat ileal cytosol

Marie C. Lin, Yongzhong Gong, Kieran F. Geoghegan, Frederick A. Wilson

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1991

Language:

english

File:

PDF, 1.19 MB

english, 1991

38

Distinctive Attributes of β-Lactam Target Proteins in Acinetobacter baumannii Relevant to Development of New Antibiotics

Han, Seungil, Caspers, Nicole, Zaniewski, Richard P., Lacey, Brian M., Tomaras, Andrew P., Feng, Xidong, Geoghegan, Kieran F., Shanmugasundaram, Veerabahu

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 3.97 MB

english, 2011

39

Improved Method for Converting an Unmodified Peptide to an Energy-Transfer Substrate for a Proteinase

Geoghegan, Kieran F.

Journal:

Bioconjugate Chemistry

Year:

1996

Language:

english

File:

PDF, 244 KB

english, 1996

40

Cyclization of N-Terminal S- Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps

Geoghegan, Kieran F., Hoth, Lise R., Tan, Douglas H., Borzilleri, Kris A., Withka, Jane M., Boyd, James G.

Journal:

Journal of Proteome Research

Year:

2002

Language:

english

File:

PDF, 110 KB

english, 2002

41

Direct photocapture of bromodomains using tropolone chemical probes

Hett, Erik C., Piatnitski Chekler, Eugene L., Basak, Arindrajit, Bonin, Paul D., Denny, R. Aldrin, Flick, Andrew C., Geoghegan, Kieran F., Liu, Shenping, Pletcher, Mathew T., Sahasrabudhe, Parag, Salt

Journal:

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

42

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism

Ahn, Kay, Brown, Matthew F., Boehm, Markus, Calloway, Jessica, Che, Ye, Chen, Jinshan M., Fennell, Kimberly, Geoghegan, Kieran F, Gilbert, Adam M., Gutierrez, Jemy A., Kalgutkar, Amit S., Lanba, Adhir

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.68 MB

english, 2016

43

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system

Caspers, Nicole L., Han, Seungil, Rajamohan, Francis, Hoth, Lise R., Geoghegan, Kieran F., Subashi, Timothy A., Vazquez, Michael L., Kaila, Neelu, Cronin, Ciarán N., Johnson, Eric, Kurumbail, Ravi G.

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2016

Language:

english

File:

PDF, 654 KB

english, 2016

44

Isolation and characterization of biologically active murine interleukin-1α derived from expression of a synthetic gene in Escherichia coli

Gaston O. Daumy, Joseph M. Merenda, Alexander S. McColl, Glenn C. Andrews, Arthur E. Franke, Kieran F. Geoghegan, Ivan G. Otterness

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1989

Language:

english

File:

PDF, 4.14 MB

english, 1989

45

IP/MS analysis of human CSF Aβ following a single dose of the C-terminal anti-Aβ antibody ponezumab (PF-04360365) to Alzheimer patients

Kathleen M. Wood, Frederick McCush, James J. Conboy, Robert Durham, Barbara Tate, Martin M. Bednar, Jaren W. Landen, Kieran F. Geoghegan, Kelly R. Bales

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

46

Structural basis of latency in plasminogen activator inhibitor-1

Mottonen, James, Strand, Arne, Symersky, Jindrich, Sweet, Robert M., Danley, Dennis E., Geoghegan, Kieran F., Gerard, Robert D., Goldsmith, Elizabeth J.

Journal:

Year:

1992

File:

PDF, 930 KB

1992

47

Crystallizable HIV-1 protease derived from expression of the viral pol gene in Escherichia coli

Dennis E. Danley, Kieran F. Geoghegan, Kathryn G. Scheld, S.Edward Lee, James R. Merson, Steven J. Hawrylik, Graham A. Rickett, Mark J. Ammirati, Peter M. Hobart

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 1.63 MB

english, 1989

48

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line

Geoghegan, Kieran F., Song, Xi, Hoth, Lise R., Feng, Xidong, Shanker, Suman, Quazi, Amira, Luxenberg, Deborah P., Wright, Jill F., Griffor, Matthew C.

Journal:

Protein Expression and Purification

Year:

2013

Language:

english

File:

PDF, 986 KB

english, 2013

49

Hydrolysis of peptides by carboxypeptidase A: equilibrium trapping of the ES2 intermediate

Geoghegan, Kieran F., Galdes, Alphonse, Hanson, Graeme, Holmquist, Barton, Auld, David S., Vallee, Bert L.

Journal:

Year:

1986

Language:

english

File:

PDF, 751 KB

english, 1986

50

Reversible reductive alkylation of amino groups in proteins

Geoghegan, Kieran F., Ybarra, Donna M., Feeney, Robert E.

Journal:

Year:

1979

Language:

english

File:

PDF, 995 KB

english, 1979

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